analgesic and anti-inflammatory activity of physalis angulata linn. (solanaceae) leaf methanolic extract in swiss albino mice

physalis angulata is a medicinal plant used for the treatment of malaria, ulcer, pains and other diverse ailments. the present study evaluated the analgesic and anti-inflammatory activity of methanolic leaf extract of the plant. acetic acid-induced abdominal contraction or writhing analgesic models in swiss albino mice (13-23g) were used for studying analgesic activity of the leaf extract. 200, 300 and 400 mg/kg body weight of the extract were administered intraperitoneally. analgesic activities of the extract were compared with standard reference drug ibuprofen (100 mg/kg) and negative control. the plant extract showed a significant dose dependent analgesic effect, with 72.7% inhibition at 400 mg/kg compared to that of the 100 mg/kg standard drug ibuprofen which showed 21.2% inhibition (p< 0.05). the anti-inflammatory activity of the extract against carrageenan-induced paw edema was also dose-dependent with 62.71% inhibition at 400 mg/kg when compared to that of the standard drug with 34.31% inhibition. the study showed that p. angulata was effective in pain reduction (analgesia) and acted as a good anti-inflammatory agent, which supports the claim in traditional medicine.